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. 1982 Jul 15;298(5871):240-4.
doi: 10.1038/298240a0.

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

S G Amara, V Jonas, M G Rosenfeld, E S Ong, R M Evans

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

S G Amara et al. Nature. .

Abstract

Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression.

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