Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981:2 Suppl 2:41-4.
doi: 10.1016/0196-9781(81)90008-5.

Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities

D Bataille, C Gespach, K Tatemoto, J C Marie, A M Coudray, G Rosselin, V Mutt

Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities

D Bataille et al. Peptides. 1981.

Abstract

A bioactive form of enteroglucagon has been isolated from porcine jejuno-ileum according to its glucagon-like effect in liver. Enzymatic digestion followed by HPLC, dansylation and partial sequence analysis strongly suggests that this peptide contains the glucagon molecule (1--29) elongated at the C-terminal end by the octapeptide Lys-Arg-Asn-Lys-Asn-Ile-Ala-COOH and possibly modified in the N-terminal region. A specific action of bioactive enteroglucagon, increase in cAMP, has been found in the acid-secreting fundic part of the rat stomach. The term "oxyntomodulin" is therefore proposed to describe this peptide.

PubMed Disclaimer

Publication types

LinkOut - more resources