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. 1982 Apr 29;238(2):480-3.
doi: 10.1016/0006-8993(82)90127-5.

Two modes of activity of nicotinic acetylcholine receptor channels in sympathetic neurons

V J Skok, A A Selyanko, V A Derkach

Two modes of activity of nicotinic acetylcholine receptor channels in sympathetic neurons

V J Skok et al. Brain Res. .

Abstract

Spectral analysis of acetylcholine (ACh) noise was performed in voltage-clamped neurons of the isolated rabbit superior cervical ganglion at 34-37 degrees C and at membrane potential--80 mV. Two modes of activity were found in the ionic channels of nicotinic ACh receptors, with mean channel life-times of for fast-operating channels and for slow-operating channels. Excitatory postsynaptic current (EPSC) decays exponentially with a time constant which is very close to , indicating that the slow-operating channel activity determines the duration of EPSC. The mean value of conductance of single nicotinic ACh-receptor channel is 36 more or less 3 pS.

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