doi: 10.1016/0014-2999(82)90184-4.
Depression by chronic electroconvulsive treatment of clonidine hypotherma and [3H]clonidine binding to rat cortical membranes
- PMID: 6284527
- DOI: 10.1016/0014-2999(82)90184-4
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Depression by chronic electroconvulsive treatment of clonidine hypotherma and [3H]clonidine binding to rat cortical membranes
Eur J Pharmacol.
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Abstract
The effects of chronic electroconvulsive treatment (ECT) on the binding of [3H]clonidine and on clonidine-induced hypothermia were studied in the rat. After 10 consecutive daily treatments we observed a reduction in the hypothermic action of clonidine and a loss of the high affinity binding sites of clonidine, without changes of the low affinity binding sites. The present results are indicative of the down-regulation of alpha 2-adrenoceptors during chronic antidepressive treatment.
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