Review
doi: 10.1007/BF00915971.
The role of the human major histocompatibility complex in cytotoxic T-cell responses to virus-infected cells
- PMID: 6284788
- DOI: 10.1007/BF00915971
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Review
The role of the human major histocompatibility complex in cytotoxic T-cell responses to virus-infected cells
J Clin Immunol.
1982 Jan.
Abstract
The human major histocompatibility complex (HLA) has been demonstrated to play two roles in the generation and expression of cytotoxic T-lymphocyte responses to virus-infected cells: (1) cytotoxic T cells can only recognize viral antigens in conjunction with antigens encoded by HLA-A and -B genes; and (2) HLA-linked genes may control the capacity to generate T-cell responses to a given virus or to virus in conjunction with particular self HLA-A and -B antigens. Analysis of T-cell responses generated in vivo to Epstein-Barr virus suggests that human T cells may recognize virus in conjunction with antigens other than the class I HLA polymorphic specificities.
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