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. 1982 Mar;41(3):990-9.
doi: 10.1128/JVI.41.3.990-999.1982.

DNA sequence of the 5' terminus containing the replication origin of parvovirus replicative form DNA

S L Rhode 3rd, B Klaassen

DNA sequence of the 5' terminus containing the replication origin of parvovirus replicative form DNA

S L Rhode 3rd et al. J Virol. 1982 Mar.

Abstract

The nucleotide sequence of the 5' terminus of the parvovirus H-1 was determined. There are two orientations of the 242-base-pair terminal palindrome in native replicative form DNA, one inverted with respect to the other. Adjacent to the terminal palindrome is an AT-rich region that is noncoding and contains a 55-base-pair tandem repeat. The addition mutant of H-1, DI-1, was also sequenced in this region and shown to have three copies of the tandem repeat sequence. Similarly, the related parvovirus H-3 contains only one copy of this repeat sequence. This region contains the replication origin for parvovirus replicative form DNA replication. Some of the implications of these results are discussed.

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