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Comparative Study
. 1982 May 25;10(10):3211-9.
doi: 10.1093/nar/10.10.3211.

Nucleotide sequence definition of a major human repeated DNA, the Hind III 1.9 kb family

L Manuelidis
Free PMC article
Comparative Study

Nucleotide sequence definition of a major human repeated DNA, the Hind III 1.9 kb family

L Manuelidis. Nucleic Acids Res. .
Free PMC article

Abstract

A human Hind III 1.9 kb repeated DNA fragment was isolated and cloned in pBR322. A cloned member that hybridized predominantly to the 1.9 kb Hind III band in a digest of whole human DNA was chosen for sequencing. It is an 1894 bp fragment that shows no significant internal repeats. Few pCG residues are observed in the sequence and there are numerous stop codons. Detailed sequence comparisons confirm this is a novel class of repeats that is not related to previously characterized human satellite DNAs or Alu sequences. At least a portion of the sequence described is conserved in evolution.

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References

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