Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1982 Mar;58(677):160-4.
doi: 10.1136/pgmj.58.677.160.

Treatment of small cell lung carcinoma in association with cryptogenic fibrosing alveolitis

J R Lipton, J Winstanley, K Carroll, J J Mould, N Thatcher
Case Reports

Treatment of small cell lung carcinoma in association with cryptogenic fibrosing alveolitis

J R Lipton et al. Postgrad Med J. 1982 Mar.

Abstract

Two patients with small cell bronchogenic carcinoma associated with cryptogenic fibrosing alveolitis are described. Both patients received radiotherapy and i.v. chemotherapy with moderate dose methotrexate (100 mg/m2) and escalating high dose cyclophosphamide (1·5 g, 2·5 g, 3·5 g/m2).

Good symptomatic improvement was obtained with concurrent tumour response. No effect upon the alveolitis was observed. The pulmonary toxicity associated with methotrexate, cyclophosphamide chemotherapy and radiotherapy is described. The use of immunosuppressive agents (including cytotoxic drugs) to improve fibrosing alveolitis is also discussed

There is no apparent contraindication for intensive antitumour therapy in patients with small cell lung cancer and fibrosing alveolitis.

PubMed Disclaimer

References

    1. Br J Radiol. 1967 Nov;40(479):801-22 - PubMed
    1. Thorax. 1972 Sep;27(5):535-42 - PubMed
    1. Cancer. 1976 Feb;37(2 Suppl):1186-1200 - PubMed
    1. Ann Intern Med. 1976 Dec;85(6):769-88 - PubMed
    1. Semin Oncol. 1974 Sep;1(3):175-82 - PubMed

Publication types

Substances

LinkOut - more resources