Acyclovir chemistry and spectrum of activity
- PMID: 6285730
- DOI: 10.1016/0002-9343(82)90054-7
Acyclovir chemistry and spectrum of activity
Abstract
Most antiviral agents with activity against the herpes group of viruses belong to a class of compounds known as nucleosides. Recently, an acyclic analog of a natural nucleoside has been found to have high activity against the herpes virus. This compound, called generically acyclovir, is 9-(hydroxymethyl)guanine. Its spectrum of antiviral activity is described.
Similar articles
-
Purine acyclic nucleosides. Nitrogen isosteres of 9-[(2-hydroxyethoxy)methyl]guanine as candidate antivirals.J Med Chem. 1981 Dec;24(12):1528-31. doi: 10.1021/jm00144a033. J Med Chem. 1981. PMID: 6273561
-
Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents.Molecules. 2017 Jul 12;22(7):1167. doi: 10.3390/molecules22071167. Molecules. 2017. PMID: 28704950 Free PMC article.
-
Pyrimidine acyclic nucleosides, 1-[(2-Hydroxyethoxy)methyl]pyrimidines as candidate antivirals.J Med Chem. 1981 Jun;24(6):753-6. doi: 10.1021/jm00138a022. J Med Chem. 1981. PMID: 6265637
-
Nucleoside analogues as antiviral agents.Acta Microbiol Acad Sci Hung. 1981;28(3):289-306. Acta Microbiol Acad Sci Hung. 1981. PMID: 6272552 Review. No abstract available.
-
Tricyclic nucleoside analogues as antiherpes agents.Antiviral Res. 2006 Sep;71(2-3):134-40. doi: 10.1016/j.antiviral.2006.05.004. Epub 2006 May 30. Antiviral Res. 2006. PMID: 16780965 Review.
Cited by
-
Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.Drugs. 1983 Nov;26(5):378-438. doi: 10.2165/00003495-198326050-00002. Drugs. 1983. PMID: 6315332 Review.
-
Viral skin infections: diagnosis and treatment considerations.Drugs. 2002;62(3):479-90. doi: 10.2165/00003495-200262030-00005. Drugs. 2002. PMID: 11827561 Review.
-
Pharmacotherapy variability and precision medicine in neurocritical care.Front Neurol. 2025 Jul 18;16:1630163. doi: 10.3389/fneur.2025.1630163. eCollection 2025. Front Neurol. 2025. PMID: 40757024 Free PMC article. Review.
-
Clinical pharmacokinetics of acyclovir.Clin Pharmacokinet. 1983 May-Jun;8(3):187-201. doi: 10.2165/00003088-198308030-00001. Clin Pharmacokinet. 1983. PMID: 6342900 Review. No abstract available.
-
Treatment of recurrent eczema herpeticum in pregnancy with acyclovir.Infect Dis Obstet Gynecol. 1996;4(4):239-42. doi: 10.1155/S1064744996000452. Infect Dis Obstet Gynecol. 1996. PMID: 18476099 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources