The virion RNA species of the Kirsten murine sarcoma-leukemia virus complex released from a clonally related series of mouse cells
- PMID: 6285864
- DOI: 10.1007/BF01314448
The virion RNA species of the Kirsten murine sarcoma-leukemia virus complex released from a clonally related series of mouse cells
Abstract
We have characterized the virion RNA species of Kirsten sarcoma (KiSV) and Kirsten leukemia (KiLV) viruses released from a clonally related series of mouse cells (14). We have identified the KiLV and KiSV genome RNAs. In addition to the viral RNA species we find large amounts of a virus-like RNA (VL30 RNA), which is heterogeneous and shows variability in its expression. The amount of VL30 RNA in virions does not correlate with the state of transformation of the cells releasing the virus or the ability of the virus to transform other cells. Characterization of RNA rescued from non-producer cells has revealed a sarcoma virus (KiSV CB3) with an oligonucleotide fingerprint different from that of a standard KiSV RNA, suggesting that it has lost some viral sequences. The oligonucleotide fingerprints of KiLV and VL30 RNAs are distinct from each other and from those reported for other murine leukemia virus RNAs.
Similar articles
-
Biochemical characterization of a deleted Kirsten sarcoma virus genome. Brief report.Arch Virol. 1983;76(2):139-44. doi: 10.1007/BF01311697. Arch Virol. 1983. PMID: 6307222
-
Sequence relationships between Kirsten retrovirus genomes and the genomes of other murine retroviruses.Virology. 1983 Apr 15;126(1):126-54. doi: 10.1016/0042-6822(83)90467-1. Virology. 1983. PMID: 6302979
-
Genesis of Kirsten murine sarcoma virus: sequence analysis reveals recombination points and potential leukaemogenic determinant on parental leukaemia virus genome.Nucleic Acids Res. 1984 Sep 11;12(17):6839-52. doi: 10.1093/nar/12.17.6839. Nucleic Acids Res. 1984. PMID: 6091040 Free PMC article.
-
Virus RNA species in kirsten murine sarcoma virus-transformed mink cells.J Gen Virol. 1980 Nov;51(Pt 1):195-9. doi: 10.1099/0022-1317-51-1-195. J Gen Virol. 1980. PMID: 6257834
-
The isolation and characterization of a clonally related series of murine retrovirus-infected mouse cells.J Gen Virol. 1980 Jul;49(1):105-13. doi: 10.1099/0022-1317-49-1-105. J Gen Virol. 1980. PMID: 6252284
Cited by
-
Two unique RNA species of the nodavirus black beetle virus.J Virol. 1982 Dec;44(3):767-71. doi: 10.1128/JVI.44.3.767-771.1982. J Virol. 1982. PMID: 16789234 Free PMC article.
-
Biochemical characterization of a deleted Kirsten sarcoma virus genome. Brief report.Arch Virol. 1983;76(2):139-44. doi: 10.1007/BF01311697. Arch Virol. 1983. PMID: 6307222
-
Identification of an internal ribosome entry segment in the 5' region of the mouse VL30 retrotransposon and its use in the development of retroviral vectors.J Virol. 1999 Oct;73(10):8393-402. doi: 10.1128/JVI.73.10.8393-8402.1999. J Virol. 1999. PMID: 10482590 Free PMC article.
-
Virus-like 30S RNA is selectively packaged by Kirsten leukemia virus in virions of smaller size class. Brief report.Arch Virol. 1984;81(3-4):353-7. doi: 10.1007/BF01310006. Arch Virol. 1984. PMID: 6206827
-
A novel approach to cloning transcriptionally active retrovirus-like genetic elements from mouse cells.Nucleic Acids Res. 1983 Sep 24;11(18):6243-54. doi: 10.1093/nar/11.18.6243. Nucleic Acids Res. 1983. PMID: 6312415 Free PMC article.