Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Mar;1(1):57-68.
doi: 10.1007/BF00736039.

Characterization of the dopamine stimulated adenylate cyclase in the pedal ganglia of Mytilus edulis: interactions with etorphine, beta-endorphin, DALA, and methionine enkephalin

G B Stefano, E J Catapane, R M Kream

Characterization of the dopamine stimulated adenylate cyclase in the pedal ganglia of Mytilus edulis: interactions with etorphine, beta-endorphin, DALA, and methionine enkephalin

G B Stefano et al. Cell Mol Neurobiol. 1981 Mar.

Abstract

The dopamine-stimulated adenylate cyclase activity was studied both in vivo and in vitro in the central nervous system of the bivalve mollusc Mytilus edulis. Dopamine, epinine, and apomorphine stimulated the enzyme system. Fluphenazine, haloperidol, chlorpromaxine, and to a lesser extent BOL inhibited the dopamine-stimulated adenylate cyclase. Etorphine, beta-endorphine, DALA, and methionine enkephalin depressed cyclic AMP levels. This phenomena was naloxone reversible. In addition, the opioids inhibited the stimulation of adenylate cyclase by dopamine. This phenomena was also naloxone reversible. The study demonstrates an interaction among dopamine, the opioids, and cyclic AMP.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ary, M., Cox, B. and Lomax, P., (1977). Dopaminergic mechanism in percipitated withdrawal in morphine-dependent rats.J. Pharmacol. Exp. Ther.200271–276. - PubMed
    1. Berry, M. S., and Cottrell, G. A. (1973). Dopamine: excitatory and inhibitory transmission from a giant dopamine neurone.Nature New Biol.242250–253. - PubMed
    1. Carenzi, A., Guidotti, A., Revvelta, A., and Costa, E. (1975). Molecular mechanisms in the actions of morphine and viminol (R2) on rat striatum.J. Pharmacol. Exp. Ther.194311–318. - PubMed
    1. Catapane, E. J., Stefano, G. B., and Aiello, E. (1978). Pharmacological study of the reciprocal dual innervation of the lateral ciliated gill epithelium by the CNS ofMytilus edulis (Bivalvia).J. Exp. Bio.74101–113.
    1. Catapane, E. J., Stefano, G. B., and Aiello, E. (1979). Neurophysiological correlates of the dopaminergic cilio-inhibitory mechanism ofMytilus edulis.J. Exp. Biol.83315–323. - PubMed

Publication types

LinkOut - more resources