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. 1982 Jun;60(Pt 2):371-4.
doi: 10.1099/0022-1317-60-2-371.

The internal organization of the varicella-zoster virus genome

D H Gilden, Y Shtram, A Friedmann, M Wellish, M Devlin, N Fraser, Y Becker

The internal organization of the varicella-zoster virus genome

D H Gilden et al. J Gen Virol. 1982 Jun.

Abstract

DNA was extracted from varicella-zoster (VZ) virions prepared in sucrose gradients. Thirty-eight molecules examined by electron microscopy were found to have a mean length of 46.7 micrometers. Examination of self-annealed VZV DNA molecules revealed that the virus genome was composed of a unique linear large sequence with a mol. wt. of 74.4 X 10(6) to 78.4 X 10(6), and a unique short sequence of mol. wt. approx. 9.8 X 10(6) flanked by inverted repeat sequences of 4.7 X 10(6) mol. wt.

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