doi: 10.1128/mcb.2.1.93-96.1982.
Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation
- PMID: 6287224
- PMCID: PMC369757
- DOI: 10.1128/mcb.2.1.93-96.1982
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Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation
Mol Cell Biol.
1982 Jan.
Abstract
Gamma ray-induced mutants of Chinese hamster ovary cells lacking dihydrofolate reductase activity were screened for DNA sequence changes at the locus specifying this activity by using a cloned cDNA probe. Two of nine mutants screened displayed an altered restriction fragment pattern suggesting the occurrence of DNA deletions or rearrangements.
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