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. 1982 Jan;2(1):93-6.
doi: 10.1128/mcb.2.1.93-96.1982.

Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation

L H Graf Jr, L A Chasin

Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation

L H Graf Jr et al. Mol Cell Biol. 1982 Jan.

Abstract

Gamma ray-induced mutants of Chinese hamster ovary cells lacking dihydrofolate reductase activity were screened for DNA sequence changes at the locus specifying this activity by using a cloned cDNA probe. Two of nine mutants screened displayed an altered restriction fragment pattern suggesting the occurrence of DNA deletions or rearrangements.

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