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. 1982 May;319(2):168-71.
doi: 10.1007/BF00503932.

Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS

P Bousquet, J Feldman, R Bloch, J Schwartz

Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS

P Bousquet et al. Naunyn Schmiedebergs Arch Pharmacol. 1982 May.

Abstract

Microinjections of GABA and of the specific agonist of GABA receptors, muscimol, in the intermediate nucleus tractus solitarii (NTS) of pentobarbitone anaesthetized cats produced hypertension and tachycardia. The GABA receptor antagonist, bicuculline, had opposite effects and prevented those of muscimol. Therefore, a GABAergic system appears to modulate the cardiovascular regulation within the NTS. d,l-Baclofen also increased blood pressure and heart rate when injected into the same region, but this effect was not antagonized by bicuculline. The mechanism of this action of baclofen is discussed.

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References

    1. Br J Pharmacol. 1976 Dec;58(4):593-8 - PubMed
    1. Prog Brain Res. 1977;47:9-34 - PubMed
    1. Eur J Pharmacol. 1978 Apr 1;48(3):329-30 - PubMed
    1. Pflugers Arch. 1969;306(1):1-19 - PubMed
    1. J Physiol. 1979 Nov;296:100P-101P - PubMed

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