[Safety of foot-and-mouth disease vaccines in cell cultures]

Abstract

Experiments were carried out to test imported and home-produced production and experimental series of foot- and-mouth vaccines in cell cultures. It was found that the primary cell cultures of swine kidney were most appropriate to study the innocuity of the F. M. D. vaccines, which, in terms of sensitivity proved of superior quality as compared to the primary cell cultures of calf kidney and the BHK 21 cells. Comparative investigations have revealed that the most promising method for testing the innocuity of the F. M. D. vaccines is the elution of the antigen from the aluminium hydroxide after Dannacher and coll. The problem is discussed of using cell cultures to check the innocuity of F. M. D. vaccines prior to their release.