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Case Reports
. 1982 Jan-Feb;55(1):59-63.

Epstein-Barr virus in cerebrospinal fluid during infectious mononucleosis encephalitis

J A Schiff, J A Schaefer, J E Robinson
Case Reports

Epstein-Barr virus in cerebrospinal fluid during infectious mononucleosis encephalitis

J A Schiff et al. Yale J Biol Med. 1982 Jan-Feb.

Abstract

Epstein-Barr virus (EBV) was recovered from cerebrospinal cells (but not from cell-free fluid) of a patient with meningoencephalitis complicating infectious mononucleosis. This finding suggests that virus-altered B lymphocytes can invade the central nervous system and may play a direct role in the pathogenesis of neurologic sequelae of EBV infections. Several mechanisms by which these cells can cause neurologic manifestations are discussed.

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