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. 1978 Mar 24;199(4335):1345-6.
doi: 10.1126/science.628842.

Nonhistone proteins HMG1 and HMG2 change the DNA helical structure

K Javaherian, J F Liu, J C Wang

Nonhistone proteins HMG1 and HMG2 change the DNA helical structure

K Javaherian et al. Science. .

Abstract

Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.

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