doi: 10.1073/pnas.79.15.4761.
IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells
- PMID: 6289317
- PMCID: PMC346757
- DOI: 10.1073/pnas.79.15.4761
Item in Clipboard
IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells
Proc Natl Acad Sci U S A.
1982 Aug.
Abstract
Monoclonal antibodies of IgG2a isotype specifically inhibited growth of human tumors in nude mice. Twenty-three monoclonal antibodies of other isotypes showed no tumoricidal reactivity. Complement depletion of nude mice had no effect on tumor suppression by monoclonal antibody. The role of T and killer cells as mediators of the monoclonal antibody effect in nude mice was virtually excluded. On the other hand, macrophages were strongly incriminated as effector cells because silica treatment of nude mice abolished the tumoricidal effect of monoclonal antibody. IgG2a monoclonal antibody-dependent macrophage-mediated cytotoxicity assays with human tumor cells in culture resulted in specific lysis of tumor cells.
Similar articles
-
Tumors undergoing rejection induced by monoclonal antibodies of the IgG2a isotype contain increased numbers of macrophages activated for a distinctive form of antibody-dependent cytolysis.Proc Natl Acad Sci U S A. 1984 Jun;81(11):3506-10. doi: 10.1073/pnas.81.11.3506. Proc Natl Acad Sci U S A. 1984. PMID: 6587365 Free PMC article.
-
Mechanism of antitumor activity in mice for anti-epidermal growth factor receptor monoclonal antibodies with different isotypes.Cancer Res. 1986 Nov;46(11):5592-8. Cancer Res. 1986. PMID: 3756906
-
Monoclonal antibodies specific for the neu oncogene product directly mediate anti-tumor effects in vivo.Oncogene. 1988 Apr;2(4):387-94. Oncogene. 1988. PMID: 2896329
-
Targeted cellular immunotherapy with bifunctional antibodies.Cancer Cells. 1991 May;3(5):163-72. Cancer Cells. 1991. PMID: 1832553 Review.
-
Manipulation of the intratumor infiltrate by anti-tumor antibody conjugates.Biochim Biophys Acta. 1987 Jul 8;907(2):175-90. doi: 10.1016/0304-419x(87)90005-9. Biochim Biophys Acta. 1987. PMID: 3297156 Review. No abstract available.
Cited by
-
In vivo T cell tumor therapy with monoclonal antibody directed to the V beta chain of T cell antigen receptor.J Exp Med. 1989 Nov 1;170(5):1513-9. doi: 10.1084/jem.170.5.1513. J Exp Med. 1989. PMID: 2530299 Free PMC article.
-
Inhibition of multidrug-resistant human tumor growth in athymic mice by anti-P-glycoprotein monoclonal antibodies.Jpn J Cancer Res. 1989 Jul;80(7):627-31. doi: 10.1111/j.1349-7006.1989.tb01688.x. Jpn J Cancer Res. 1989. PMID: 2571602 Free PMC article.
-
Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity.Proc Natl Acad Sci U S A. 1988 Jul;85(13):4852-6. doi: 10.1073/pnas.85.13.4852. Proc Natl Acad Sci U S A. 1988. PMID: 3387441 Free PMC article.
-
Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.Proc Natl Acad Sci U S A. 1987 May;84(10):3390-4. doi: 10.1073/pnas.84.10.3390. Proc Natl Acad Sci U S A. 1987. PMID: 3494997 Free PMC article.
-
Anti-idiotype immunization of cancer patients: modulation of the immune response.Proc Natl Acad Sci U S A. 1987 Nov;84(22):8055-9. doi: 10.1073/pnas.84.22.8055. Proc Natl Acad Sci U S A. 1987. PMID: 3500471 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
