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. 1982 Jul;22(1):176-9.
doi: 10.1128/AAC.22.1.176.

Inhibition of herpes simplex virus replication by methyl daunosamine

J G Spivack, W H Prusoff, T R Tritton

Inhibition of herpes simplex virus replication by methyl daunosamine

J G Spivack et al. Antimicrob Agents Chemother. 1982 Jul.

Abstract

Methyl daunosamine inhibited the replication of herpes simplex virus type 1 in a dose-dependent manner. The growth of the host Vero cells was not affected by daunosamine levels that had significant antiviral activity (2.5 mM) but was inhibited by concentrations of 5 mM or greater. Methyl daunosamine appears to be unique among the sugars with antiviral activity because at antiviral concentrations it did not inhibit the glycosylation of macromolecules.

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