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. 1982 Jul 15;206(1):181-4.
doi: 10.1042/bj2060181.

Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma

H C Freake, I MacIntyre

Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma

H C Freake et al. Biochem J. .

Abstract

A specific 1,25-dihydroxycholecalciferol-binding protein has been detected in high-salt cytosols prepared from human medullary thyroid carcinomas. The binding protein had the same equilibrium dissociation constant (Kd = 0.17 +/- 0.05 nM; n = 4) and sedimentation coefficient on sucrose gradients (3.7S) as than seen in established vitamin D target tissues. This protein was not detected in normal thyroid cytosols, which may reflect the low proportion of C-cells within the gland.

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