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. 1982;17(4):222-7.
doi: 10.1159/000149292.

Characterization of SV40-transformed human liver cells before and after passage through crisis

J Buitenwerf, W de Jong, A van Strien, J van der Noordaa

Characterization of SV40-transformed human liver cells before and after passage through crisis

J Buitenwerf et al. Intervirology. 1982.

Abstract

SV40-transformed human liver cells could be passed through crisis after transfection with various DNAs (SV40, BKV, or salmon sperm). The pre- and post-crisis cells were compared with respect to growth behavior and the state of the viral genome. Comparison of the viral inserts in the pre- and post-crisis cells showed minor changes in the integration pattern of the SV40 DNA after recovery from crisis.

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