Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Mar;12(1):45-9.
doi: 10.1007/BF00926910.

Uracil synthesis via HCN oligomerization

A B Voet, A W Schwartz

Uracil synthesis via HCN oligomerization

A B Voet et al. Orig Life. 1982 Mar.

Abstract

Uracil is released from HCN oligomers upon acid hydrolysis in concentrations of 0.001% for 1 M HCN solutions to 0.005% for 0.1 M solutions. This yield is comparable with earlier reported, minor or nonbiological pyrimidines such as 5-hydroxyuracil and orotic acid. This is the first report of uracil itself via HCN oligomerization. Data are presented which establish that the observed uracil is not formed by decarboxylation of previously formed orotic acid, but via acid hydrolysis of at least two other precursors.

PubMed Disclaimer

References

    1. Biosystems. 1977 Sep;9(2-3):81-6 - PubMed
    1. Nature. 1961 Apr 29;190:442-3 - PubMed
    1. J Am Chem Soc. 1965 Nov 5;87(21):4976-7 - PubMed
    1. Science. 1961 Jun 16;133(3468):1923-4 - PubMed
    1. Biosystems. 1977 Sep;9(2-3):87-92 - PubMed