Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Sep;22(3):518-9.
doi: 10.1128/AAC.22.3.518.

Synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam

H C Neu

Synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam

H C Neu. Antimicrob Agents Chemother. 1982 Sep.

Abstract

The beta-lactamase inhibitors clavulanic acid and sulbactam were combined with mecillinam. beta-Lactamase-containing Escherichia coli resistant to mecillinam was synergistically inhibited by both clavulanic acid and sulbactam. beta-Lactamase-containing Enterobacter was synergistically inhibited, but strains lacking beta-lactamases were not synergistically inhibited. Synergistic inhibition was noted for beta-lactamase-containing, mecillinam-resistant Klebsiella, Citrobacter, Serratia, and Salmonella isolates, but only 18% of beta-lactamase-containing Proteus mirabilis, Providencia rettgeri, Providencia stuartii, and Morganella morganii were synergistically inhibited by the combinations.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Antimicrob Agents Chemother. 1972 Apr;1(4):283-8 - PubMed
    1. J Antibiot (Tokyo). 1976 Jun;29(6):668-9 - PubMed
    1. Antimicrob Agents Chemother. 1976 May;9(5):793-9 - PubMed
    1. J Antimicrob Chemother. 1977 Jul;3 Suppl B:29-39 - PubMed
    1. Antimicrob Agents Chemother. 1978 Sep;14(3):414-9 - PubMed

LinkOut - more resources