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. 1982 Nov;41(13):2933-9.

Intracellular modulation of membrane channels by cyclic AMP-mediated protein phosphorylation in peptidergic neurons of Aplysia

F Strumwasser, L K Kaczmarek, K R Jennings
  • PMID: 6292000

Intracellular modulation of membrane channels by cyclic AMP-mediated protein phosphorylation in peptidergic neurons of Aplysia

F Strumwasser et al. Fed Proc. 1982 Nov.

Abstract

The peptidergic bag cell neurons of the opisthobranch mollusc Aplysia control egg laying and its correlated behavior by release of the neuroactive peptide, egg-laying hormone, during the extended electrical discharge termed afterdischarge. This paper examines the evidence for the involvement of cyclic AMP (cAMP) and protein phosphorylation in the mediation of this electrical afterdischarge. It is concluded that an important component in the mechanism of afterdischarge is the suppression of a potassium channel, mediated by cAMP-dependent protein kinase-induced protein phosphorylation. The exact identity of the potassium channel remains to be worked out.

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