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. 1982 Sep 11;10(17):5133-47.
doi: 10.1093/nar/10.17.5133.

Epsilon globin gene transcripts originating upstream of the mRNA cap site in K562 cells and normal human embryos

M Alan, G J Grindlay, L Stefani, J Paul

Epsilon globin gene transcripts originating upstream of the mRNA cap site in K562 cells and normal human embryos

M Alan et al. Nucleic Acids Res. .

Abstract

RNA transcribed from the human epsilon globin gene was studied in K562 cells and human embryos of 5-10 weeks gestation. Using both primer extension and S1 analysis RNA molecules were found which extend 53 +/- 1 bp, 55 +/- 1 bp and 270 +/- 1 bp upstream from the first coding base and are colinear with the gene. The first pair of molecules represent transcripts initiating at the canonical cap site but the other species represents a transcript over 200 nucleotides longer which initiates upstream of the CAAT and ATAA boxes.

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