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. 1982 Nov;79(21):6627-30.
doi: 10.1073/pnas.79.21.6627.

Human type I procollagen genes are located on different chromosomes

C Huerre, C Junien, D Weil, M L Chu, M Morabito, N Van Cong, J C Myers, C Foubert, M S Gross, D J Prockop, A Boué, J C Kaplan, A de la Chapelle, F Ramirez

Human type I procollagen genes are located on different chromosomes

C Huerre et al. Proc Natl Acad Sci U S A. 1982 Nov.

Abstract

A recombinant plasmid containing sequences complementary to human pro-alpha l(I) collagen mRNA was used for the chromosomal assignment of the pro-alpha l(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosomes with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-alpha l(I) gene with the segment 17q21 leads to qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.

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