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. 1982;78(1):71-5.
doi: 10.1007/BF00470592.

Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes

S Liljequist, J Engel

Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes

S Liljequist et al. Psychopharmacology (Berl). 1982.

Abstract

The interaction between ethanol and various GABAergic drugs (muscimol, bicuculline, picrotoxin) with regard to their effects on locomotor activity, drug-induced sleep, body temperature, and convulsions was studied. It was demonstrated that the GABA receptor agonist muscimol potentiated the sedative properties of ethanol, while the opposite effect, a reduction of ethanol-produced sedation, was seen upon administration of the GABA receptor blocking agent picrotoxin. Consequently, the results from the present series of experiments indicate that ethanol enhances central GABAergic activity.

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