Sodium currents in human skeletal muscle fibers

Abstract

Sodium currents from human external intercostal muscle fibers were recorded using the Hille-Campbell voltage clamp method. Sodium currents are analyzed in terms of the m and h parameters of the Hodgkin-Huxley model. The results indicate that the kinetics and voltage dependence of sodium currents in human skeletal muscle fibers are very similar to those reported in rat fibers.