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Clinical Trial
. 1982 Dec;22(6):1004-7.
doi: 10.1128/AAC.22.6.1004.

Topical enviroxime against rhinovirus infection

R A Levandowski, C T Pachucki, M Rubenis, G G Jackson
Clinical Trial

Topical enviroxime against rhinovirus infection

R A Levandowski et al. Antimicrob Agents Chemother. 1982 Dec.

Abstract

Enviroxime, an inhibitor of rhinovirus replication, was studied in a double-blind, placebo-controlled trial with 99 volunteers. The efficacy of a nasal-spray formulation of enviroxime was tested as pretreatment or as postchallenge treatment for rhinovirus type 4 infection. In the regimens used, drug administration neither prevented infection nor reduced the frequency of specific colds. The mean concentration of enviroxime in nasal washes (12 h after a dose) differentiated two groups of responders. Those in whom the drug concentration exceeded 100 ng/ml had some benefits, although these were statistically insignificant.

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References

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