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. 1982 Nov;2(11):1459-62.
doi: 10.1128/mcb.2.11.1459-1462.1982.

Alterations of gene structure in ethyl methane sulfonate-induced mutants of mammalian cells

M Meuth, J E Arrand

Alterations of gene structure in ethyl methane sulfonate-induced mutants of mammalian cells

M Meuth et al. Mol Cell Biol. 1982 Nov.

Abstract

To determine the types of alterations in gene structure induced by DNA-alkylating agents, we analyzed the restriction enzyme cleavage patterns of adenine phosphoribosyltransferase gene sequences in mutant strains of Chinese hamster ovary cells deficient in this enzyme. Base pair changes as detected by loss of restriction enzyme sites were found, but no major internal gene rearrangements could be detected.

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