Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Dec 20;10(24):7965-76.
doi: 10.1093/nar/10.24.7965.

Transcriptional 'enhancers' from SV40 and polyoma virus show a cell type preference

J de Villiers, L Olson, C Tyndall, W Schaffner

Transcriptional 'enhancers' from SV40 and polyoma virus show a cell type preference

J de Villiers et al. Nucleic Acids Res. .

Abstract

Transcriptional "enhancers" have been identified in both the monkey virus SV40 and in the mouse polyoma virus. Here we report that these enhancers show a cell type preference. This was done, (i) by assaying for T antigen expression and viral DNA replication of polyoma DNA which contains its own enhancer or the enhancer of SV40 virus, and (ii) by linking either of the two enhancer elements to the rabbit beta 1-globin gene and measuring transient globin expression in mouse and primate cells. The results were consistent in all the assays: In mouse cells the polyoma enhancer is slightly more effective than the SV40 enhancer. However, in primate cells the SV40 enhancer induces a four to six fold higher level of gene expression than does the polyoma enhancer.

PubMed Disclaimer

References

    1. Cell. 1981 Mar;23(3):809-14 - PubMed
    1. Nature. 1981 Apr 23;290(5808):720-2 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Feb;78(2):943-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Mar;78(3):1411-5 - PubMed
    1. Nucleic Acids Res. 1981 Nov 25;9(22):6047-68 - PubMed

Publication types