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. 1983 Mar 11;11(5):1361-73.
doi: 10.1093/nar/11.5.1361.

Methylation of the chicken vitellogenin gene: influence of estradiol administration

F C Meijlink, J N Philipsen, M Gruber, G Ab
Free PMC article

Methylation of the chicken vitellogenin gene: influence of estradiol administration

F C Meijlink et al. Nucleic Acids Res. .
Free PMC article

Abstract

The degree of methylation of the chicken vitellogenin gene has been investigated. Upon induction by administration of estradiol to a rooster, methyl groups at specific sites near the 5'-end of the gene are eliminated. The process of demethylation is slower than the activation of the gene. Demethylation is therefore probably not a prerequisite to gene transcription. At least two other sites in the coding region of the gene are methylated in the liver of estrogenized roosters, but not in the liver of a laying hen, where the gene is naturally active.

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References

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