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. 1983 Feb;80(3):678-82.
doi: 10.1073/pnas.80.3.678.

Characterization and partial nucleotide sequence of endogenous type C retrovirus segments in human chromosomal DNA

R Repaske, R R O'Neill, P E Steele, M A Martin

Characterization and partial nucleotide sequence of endogenous type C retrovirus segments in human chromosomal DNA

R Repaske et al. Proc Natl Acad Sci U S A. 1983 Feb.

Abstract

Twenty-six different murine leukemia virus (MuLV)-related clones have been isolated from a human DNA library and characterized by restriction enzyme mapping and reciprocal nucleic acid hybridization reactions. The sequence of approximately 2,600 nucleotides, spanning more than 4.0 kilobases, of one of the MuLV-related cloned human DNAs was also determined. The deduced amino acid sequence permitted the alignment of this prototype cloned human DNA segment with the p12 gag, p30 gag, p10 gag, and pol regions of Moloney MuLV. A majority of the endogenous type C retrovirus-related segments present in human DNA are approximately 6.0 kilobases in size and appear to contain a deletion of env sequences.

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