Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Feb;35(1):56-60.
doi: 10.1136/oem.35.1.56.

Simultaneous determination by gas chromatography of the major metabolites in urine of toluene, xylenes and styrene

P B Van Roosmalen, I Drummond

Simultaneous determination by gas chromatography of the major metabolites in urine of toluene, xylenes and styrene

P B Van Roosmalen et al. Br J Ind Med. 1978 Feb.

Abstract

A gas chromatographic method has been developed to determine the following metabolites in urine simultaneously if necessary: hippuric acid from toluene or styrene; 3- and 4-methyl hippuric acids from xylenes; phenylglyoxylic acid and mandelic acid from styrene. Heptadecanoic acid is added to the urine as an internal standard and after ethyl acetate extraction from acidic solution, the trimethylsilyl (TMS) derivatives of the metabolites are formed and simultaneously analysed by gas chromatography on 3% OV-1 on 80/100 gas chrom Q (flame ionisation detector).

PubMed Disclaimer

References

    1. Clin Chem. 1963 Feb;9:91-6 - PubMed
    1. J Lab Clin Med. 1961 May;57:813-8 - PubMed
    1. Ann N Y Acad Sci. 1976;271:396-409 - PubMed
    1. Br J Ind Med. 1973 Apr;30(2):125-8 - PubMed
    1. Br J Ind Med. 1969 Oct;26(4):330-4 - PubMed

LinkOut - more resources