Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Jan;23(1):105-7.
doi: 10.1128/AAC.23.1.105.

Effects of pH on the activity of ketoconazole against Candida albicans

H Minagawa, K Kitaura, N Nakamizo

Effects of pH on the activity of ketoconazole against Candida albicans

H Minagawa et al. Antimicrob Agents Chemother. 1983 Jan.

Abstract

The activity of ketoconazole against Candida albicans in Sabouraud glucose medium was markedly influenced by pH. Minimum inhibitory concentrations of this imidazole against both a standard strain and clinical isolates ranged from 40 mug/ml at pH 3 to 0.02 mug/ml at pH 7, a greater than 1,000-fold difference.

PubMed Disclaimer

References

    1. J Clin Pathol. 1975 Oct;28(10):767-74 - PubMed
    1. J Infect Dis. 1978 Aug;138(2):245-8 - PubMed
    1. Experientia. 1979 May 15;35(5):606-7 - PubMed
    1. J Med Chem. 1979 Aug;22(8):1003-5 - PubMed
    1. J Antimicrob Chemother. 1980 Jan;6(1):97-104 - PubMed

MeSH terms

LinkOut - more resources