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. 1982:12:237-47.

Structure and function of the hepatitis B virus genome

H Will, C Kuhn, R Cattaneo, H Schaller
  • PMID: 6300022

Structure and function of the hepatitis B virus genome

H Will et al. Princess Takamatsu Symp. 1982.

Abstract

A preliminary map of the hepatitis B virus genome has been derived from the nucleotide sequence of cloned human hepatitis virus (HBV) DNA. The genes for two viral antigens were identified and their expression was studied using SV40 vector systems. HBV DNA cloned and amplified in bacteria induces hepatitis in chimpanzees demonstrating that the cloned HBV DNA is functionally intact.

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