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. 1978 Mar;5(3):220-3.
doi: 10.1002/bms.1200050310.

Quantitative determination of nifedipine in human plasma by selected ion monitoring

S Higuchi, Y Shiobara

Quantitative determination of nifedipine in human plasma by selected ion monitoring

S Higuchi et al. Biomed Mass Spectrom. 1978 Mar.

Abstract

A highly sensitive and specific method for the determination of nifedipine in plasma is described. Nifedipine was oxidized to its pyridine analogue with nitrous acid and determined by selected ion monitoring. Deuterium labeled nifedipine was used as an internal standard. Plasma levels as low as 5 ng ml-1 were measured. The usefulness of the method was demonstrated by obtaining plasma concentration curves for humans after an oral dose of 10 mg.

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