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Comparative Study
. 1983 Jan;80(2):505-9.
doi: 10.1073/pnas.80.2.505.

H-2-linked regulation of xenotropic murine leukemia virus expression

R A Yetter, J W Hartley, H C Morse 3rd
Comparative Study

H-2-linked regulation of xenotropic murine leukemia virus expression

R A Yetter et al. Proc Natl Acad Sci U S A. 1983 Jan.

Abstract

A high proportion of lymphocytes from F/St mice produce infectious xenotropic murine leukemia virus (X-MuLV) and express high levels of cell surface antigens, termed XenCSA, related to the major glycoprotein of X-MuLV. In crosses of F/St with AKR, the high-virus phenotype of F/St was found to be recessive and was shown to be governed by a single locus, Cxv-1, less than 2 centimorgans from H-2K. The close association of Cxv-1 with the H-2 complex was confirmed by the observation that B10.F mice, congeneic for the H-2 region of F/St, expressed high levels of infectious X-MuLV and XenCSA, whereas C57BL/10 mice and other C57BL/10 H-2 congeneic strains did not. Studies of hybrid mice homozygous for Cxv-1s, but segregating for a chromosome 1 X-MuLV induction locus (V locus) of F/St, demonstrated that the high-virus phenotype of F/St was dependent on the interaction between Cxv-1 and the chromosome 1 V locus.

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