[Level of cyclic nucleotides (cAMP and cGMP), ATPase activity and calcium ion transport in hamster lymphocytes during tumor growth]

Abstract

The biochemical systems of lymphocytes of the peripheral blood and lymph nodes of hamsters with a herpes simplex (type 2) virus--induced transplantable tumor Rapp HSV2 were studied. The cAMP concentration in tumor-bearing hamsters was 1.5-2 times higher, while cGMP level--2.2 times lower than in control. This was matched by a rise in the level of transport ATPases in the lymphocytes of experimental animals. Concanavalin A had practically no effect on the uptake of Ca2+ by lymphocytes of tumor-bearing animals. The stimulating effect on the blasttransformation of those lymphocytes was slight. It is suggested that the said biochemical changes in their totality inhibit the activation of lymphocytes in the tumor-bearing organism.