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. 1983 Feb;23(2):332-4.
doi: 10.1128/AAC.23.2.332.

Effect of acyclovir on viral protein synthesis in cells infected with herpes simplex virus type 1

P A Furman, P V McGuirt

Effect of acyclovir on viral protein synthesis in cells infected with herpes simplex virus type 1

P A Furman et al. Antimicrob Agents Chemother. 1983 Feb.

Abstract

The effect of the antiviral agent 9-(2-hydroxyethoxymethyl)guanine (acyclovir) on herpes simplex virus type 1 protein synthesis during virus replication was examined. Treatment of infected cells with acyclovir markedly affected the amounts of the four major glycosylated and certain non-glycosylated viral polypeptides synthesized; other viral polypeptides were made in normal amounts. The reduced amount of late protein synthesis was most likely due to the inhibition of progeny viral DNA synthesis by acyclovir.

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