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. 1983 Jan 28;87(1):155-8.
doi: 10.1016/0014-2999(83)90064-x.

The picrotoxin-like action of a convulsant benzodiazepine, Ro5-3663

N L Harrison, M A Simmonds

The picrotoxin-like action of a convulsant benzodiazepine, Ro5-3663

N L Harrison et al. Eur J Pharmacol. .

Abstract

The potency and site of action of Ro5-3663 as a GABA antagonist were investigated in the rat cuneate slice in vitro. A Schild plot for Ro5-3663 was clearly non-linear but enabled a pA2 value of 3.97 to be calculated. Combination studies using the 'classical' GABA antagonists bicuculline and picrotoxin indicated that Ro5-3663 acted at a separate site from bicuculline, but may share a common site with picrotoxin.

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