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. 1983 Jun;303(5919):674-9.
doi: 10.1038/303674a0.

Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences

A Nordheim, A Rich

Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences

A Nordheim et al. Nature. 1983 Jun.

Abstract

Three 8-base pair (bp) segments of alternating purine-pyrimidine from the simian virus 40 enhancer region form Z-DNA on negative supercoiling; minichromosome DNase I-hypersensitive sites determined by others bracket these three segments. A survey of transcriptional enhancer sequences reveals a pattern of potential Z-DNA-forming regions which occur in pairs 50-80 bp apart. This may influence local chromatin structure and may be related to transcriptional activation.

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