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. 1983 Apr 25;11(8):2273-85.
doi: 10.1093/nar/11.8.2273.

The human thyroglobulin gene contains two 15-17 kb introns near its 3'-end

G J van Ommen, A C Arnberg, F Baas, H Brocas, A Sterk, W H Tegelaers, G Vassart, J J de Vijlder
Free PMC article

The human thyroglobulin gene contains two 15-17 kb introns near its 3'-end

G J van Ommen et al. Nucleic Acids Res. .
Free PMC article

Abstract

We have cloned overlapping segments of the human thyroglobulin gene from a genomic cosmid library. Restriction mapping and electron microscopy show that a region of 38 kb at or near the 3'-end of this gene encodes only 850 nucleotides or 10% of the messenger RNA (mRNA) sequence. The region contains five exons of 130-210 nucleotides, split by introns of 1 to 15-17 kb. This represents the lowest ratio of coding to non-coding DNA (2.2%) found thus far in any eukaryotic gene. Blot hybridization under non-stringent conditions shows the presence of only one copy of this gene in the human genome and the absence of other closely related sequences.

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