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. 1983 Jul;304(5921):35-9.
doi: 10.1038/304035a0.

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

M D Waterfield, G T Scrace, N Whittle, P Stroobant, A Johnsson, A Wasteson, B Westermark, C H Heldin, J S Huang, T F Deuel

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

M D Waterfield et al. Nature. 1983 Jul.

Abstract

A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.

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