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. 1982;2(8):565-7.
doi: 10.3109/02713688209069182.

The effect of cyclic AMP on the rabbit corneal endothelial fluid pump

O Neuwirth, S Dikstein

The effect of cyclic AMP on the rabbit corneal endothelial fluid pump

O Neuwirth et al. Curr Eye Res. 1982.

Abstract

Perfusing preswollen deepithelialized rabbit cornea in vitro on its endothelial side with balanced salt solution containing physiological glucose concentration and 10(-6)M adenosine, we can obtain "temperature reversal" from 500-520 microns to less than 400 microns, during 7 hours. Low concentrations of adenosine improve the fluid pump supposedly by inhibiting adenylate cyclase, since c-AMP inhibits the pump.

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