Infection of baboons ("Papio cynocephalus") with rotavirus (SA11)

Abstract

A recent survey of nonhuman primate sera indicated that antibody to a rotavirus (SA11) was prevalent among a wide spectrum of animals. Both New and Old World species were found with antibody, many with surprisingly high titers (1:320). Whether or not infection per se was due to SA11 or an antigenically closely related agent could not be determined by that study; however, it is apparent from this study as well as from a survey of the literature that natural as well as experimental infection of nonhuman primates occurs. Recognizing that there is a need for an animal model for the study of viruses associated with human diarrhea, a preliminary investigation attempting to ascertain the susceptibility of the baboon (Papio cynocephalus) to a rotavirus was undertaken. Inoculation of four newborn baboons with SA11 resulted in diarrhea within 24 to 48 hours in all animals. One animal died 10 days postinoculation following severe diarrhea and dehydration. Virus was isolated as well as seen by electron microscopy in the stools of all four animals.