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. 1983 Aug;33(8):966-70.
doi: 10.1212/wnl.33.8.966.

ACTH and prednisone in childhood seizure disorders

O C Snead 3rd, J W Benton, G J Myers

ACTH and prednisone in childhood seizure disorders

O C Snead 3rd et al. Neurology. 1983 Aug.

Abstract

We treated 116 children with ACTH or prednisone. Fifty-two had infantile spasms with hypsarhythmia, and 64 had other types of intractable seizures. ACTH completely controlled seizures in all patients with infantile spasms and hypsarhythmia and 74% of those with other types of seizures. Prednisone controlled 51% of patients with infantile spasms and none with other seizures. Serious side effects were minimal for both drugs, and recurrent seizures occurred in 40 to 50% of patients within 4 to 14 months after completion of therapy.

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