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Comparative Study
. 1983 Aug 11;11(15):5055-71.
doi: 10.1093/nar/11.15.5055.

The complete nucleotide sequence of the I-E alpha d immune response gene

J J Hyldig-Nielsen, L Schenning, U Hammerling, E Widmark, E Heldin, P Lind, B Servenius, T Lund, R Flavell, J S Lee, J Trowsdale, P H Schreier, F Zablitzky, D Larhammar, P A Peterson, L Rask
Free PMC article
Comparative Study

The complete nucleotide sequence of the I-E alpha d immune response gene

J J Hyldig-Nielsen et al. Nucleic Acids Res. .
Free PMC article

Abstract

We have isolated and sequenced the complete murine I-E alpha immune response gene of the H-2db haplotype. The I-E alpha d gene consists of 5300 basepairs and is organized into five or possibly six exons that correspond to different domains of the alpha chain. The amino acid sequence deduced from the I-E alpha gene shows 75% homology to its human counterpart, the HLA-DR alpha chain. The absence of I-E antigen in H-2 mice is due to lack of E alpha chain synthesis. We show here that this defect is caused by a deletion in the 5' end of the I-E alpha b gene.

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References

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