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. 1983 May 15;212(2):517-20.
doi: 10.1042/bj2120517.

Histamine H2 receptors on foetal-bovine articular chondrocytes

D J Taylor, J R Yoffe, D E Woolley

Histamine H2 receptors on foetal-bovine articular chondrocytes

D J Taylor et al. Biochem J. .

Abstract

The dose-response curve of histamine-induced cyclic AMP elevation in monolayer cultures of primary foetal-bovine articular chondrocytes was displaced to the right by cimetidine. In addition, H2 but not H1 antagonists prevented the histamine-induced cyclic AMP elevation, suggesting histamine activates chondrocyte adenylate cyclase through an H2 receptor.

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